IUPAC-NIST Solubility Database
NIST Standard Reference Database 106

Glass Ball as Bullet Solubility System: 2,4,6-Trichloro-3,5-dimethylphenol with Water
Components:
   (1) Water; H2O; [7732-18-5]  NIST Chemistry WebBook for detail
   (2) 2,4,6-Trichloro-3,5-dimethylphenol; C8H7Cl3O; [6972-47-0]  NIST Chemistry WebBook for detail
Original Measurements:
   Blackman, G.E.; Park, M.H.; Garton, G., Arch. Biochem. Biophys. 1955, 54(1), 55-71.

 Variables:
   Temperature = One temperature   
pH = 5.1

 Prepared By:
   F. W. Getzen

 Experimental Data:   (Notes on the Nomenclature)
  
t/°C103 * g1/V2 [g dm**-3]105 * Concentration c1 [mol dm**-3]Concent. c1 Note107 * Mole Fraction x1x1 Note
254.962.2b3.98a
 Notes:
   a  Calculated by compiler.
   b  Reported.
   b  Reported value measured at pH 5.1.

 Method/Apparatus/Procedure:
   Equilibrium was established by mixing the solute with distilled water buffered with KH2PO4 at a pH of 5.1 in a glass-stoppered bottle suspended in a thermostat bath at 25°C. The sample was shaken periodically for 2 days with appropriate adjustment of pH to 5.1. After the pH became stabilized (usually about 1 week), the sample was equilibrated for an additional 2 weeks to assure saturation. Concentration was determined either directly by spectrophotometric techniques or by a colorimetric method based upon that given by (1) in which suitable colorizing agents (2,3) were added either to the saturated solution or to an appropriately diluted solution to yield an optical density proportional to the solute concentration. Concentration was obtained as the average of three replicate measurements.

 Source and Purity of Materials:
   (1) Probably a commercial reagent.
   (2) Distilled water.

 Estimated Errors:
   Solubility: <5% (evaluated on the basis of the reported results of the two analytical techniques.

 References:
   1Snell, F. D.; Snell, C. T. "Colorimetric Methods of Analysis", Vol. II; Chapman and Hall: London, England, 1936.
   2 Folin, O.; Denis, W. J. Biol. Chem. 1912, 12, 239.
   3 Folin, O.; Ciocalteu, V. J. Biol. Chem. 1927, 73, 627.