IUPAC-NIST Solubility Database
NIST Standard Reference Database 106

Glass Ball as Bullet Solubility System: Naphthalene with Acetonitrile and Water
Components:
   (1) Water; H2O; [7732-18-5]  NIST Chemistry WebBook for detail
   (2) Acetonitrile; C2H3N; [75-05-8]  NIST Chemistry WebBook for detail
   (3) Naphthalene; C10H8; [91-20-3]  NIST Chemistry WebBook for detail
Original Measurements:
   Khossaravi, D.; Connors, K.A., J. Pharm. Sci. 1992, 81, 371-379.

 Variables:
   Temperature = 298 K
   Concentration = Solvent composition

 Prepared By:
   W.E. Acree, Jr.

 Experimental Data:   (Notes on the Nomenclature)
  
t/°CConcentration c1 [mol dm**-3]Mole Fraction x2
25.02.01 x 10-40.0000
25.02.55 x 10-40.0096
25.03.49 x 10-40.0228
25.04.66 x 10-40.0330
25.06.45 x 10-40.0469
25.010.23 x 10-40.0594
25.014.17 x 10-40.0733
25.022.44 x 10-40.0887
25.050.23 x 10-40.1125
25.071.64 x 10-40.1316
25.027.45 x 10-30.1898
25.051.16 x 10-30.2280
 Notes:
   a  x2(s): initial mole fraction of binary solvent mixture; c1: molar solubility (mole dm-3) of the solute.

 Method/Apparatus/Procedure:
   Constant temperature bath, calorimetric thermometer, and an HPLC equipped with ultraviolet detection.
Binary solvent mixtures were prepared by volume. Excess solute and solvent placed in glass ampoules and allowed to equilibrate in a constant temperature water bath for 48 hours. Aliquots of the saturated solutions were removed, filtered through a 0.22 micrometer polytetrafluoroethylene membrane filter, transferred to a volumetric flask,  and diluted quantitatively to the mark. Solute concentrations were determined using reversed-phase HPLC with uv detection at 274 nm. 4-Butylbenzoic acid served as the internal standard.

 Source and Purity of Materials:
   (1) Purified Grade, Mallinckrodt, Paris, Kentucky, USA, was used as received.
   (2) HPLC grade, EM Science, Gibbstown, New Jersey, USA, was used as a received from the chemical supplier.
   (3) Was purified with a Sybron/Barnstead PCS system consisting of prefilter, organic ion exchange, and microfilter (0.2 micrometer) cartridges.

 Estimated Errors:

   Temperature: T/K: ± 0.05. x2(s): ± 0.0001 (compiler). c1: 5 % (relative error; compiler).