IUPAC-NIST Solubility Database
NIST Standard Reference Database 106

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 Solubility System: Acetonitrile with 1-Dodecanol

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Components:
   (1) 1-Dodecanol; C12H26O; [112-53-8]  NIST Chemistry WebBook for detail
   (2) Acetonitrile; C2H3N; [75-05-8]  NIST Chemistry WebBook for detail

Evaluator:
   Valerii P. Sazonov and Nikolai V. Sazonov, Technical University, Samara, Russia, November, 2001

Critical Evaluation:

           Solubilities in the system comprising acetonitrile (1) and 1-dodecanol (2) have been reported in four publications. Hoerr et al.¹ studied the phase equilibrium of the liquid-liquid-solid system and the mutual solubility of (1) and (2) between 273 and 309 K by the synthetic method. Francis² determined the upper critical solution temperature of (1) and (2) by the synthetic method. Schmid et al.³ measured of the upper critical temperature solution of components (1) and (2) in the course of a study of solubilities of binary systems of acetonitrile and (C₁₀-C₂₀) alcohols. Sazonov and Gudkina⁴ defined the mutual solubilities of acetonitrile and 1-dodecanol between 299 and 308 K by the synthetic method.
        The upper critical solution temperature has been reported as 307.7 K,³ 308.4 K,² 308.45 K,⁴ and 308.9 K,¹ these data are in reasonable agreement and thus their average value: UCST = 308.4 ± 0.5 K and is recommended. The corresponding critical solution composition has been reported as x_cl = 0.788.⁴
        Monotectic equilibrium has been reported to occur at 293.2 K.¹
        All experimental values reported ^1,4 have been approximated by an equation based on the scaling law (described in the introduction to this volume) for which the following parameters have been derived:

a₁ = 0.6791, a₂= 0.7569, b₁ = -0.4051, b₂ = -1.8542

(mean standard error of estimate was 0.0105).
        For approximation x_cl and UCST⁴ have been used. In the opinion of the evaluators, the mutual solubilities calculated by this equation may be treated as tentative. The results of calculations for the selected temperatures are presented in the following table. This relationship, together with experimental points,^1,4 are also presented in Fig. 14.
        Solubilities in the system comprising acetonitrile (1) and 1-dodecanol (2) have been reported in four publications. Hoerr et al.¹ studied the phase equilibrium of the liquid-liquid-solid system and the mutual solubility of (1) and (2) between 273 and 309 K by the synthetic method. Francis² determined the upper critical solution temperature of (1) and (2) by the synthetic method. Schmid et al.³ measured of the upper critical temperature solution of components (1) and (2) in the course of a study of solubilities of binary systems of acetonitrile and (C₁₀-C₂₀) alcohols. Sazonov and Gudkina⁴ defined the mutual solubilities of acetonitrile and 1-dodecanol between 299 and 308 K by the synthetic method.
        The upper critical solution temperature has been reported as 307.7 K,³ 308.4 K,² 308.45 K,⁴ and 308.9 K,¹ these data are in reasonable agreement and thus their average value: UCST = 308.4 ± 0.5 K and is recommended. The corresponding critical solution composition has been reported as x_cl = 0.788.⁴
        Monotectic equilibrium has been reported to occur at 293.2 K.¹
        All experimental values reported ^1,4 have been approximated by an equation based on the scaling law (described in the introduction to this volume) for which the following parameters have been derived:

a₁ = 0.6791, a₂= 0.7569, b₁ = -0.4051, b₂ = -1.8542

(mean standard error of estimate was 0.0105).
        For approximation x_cl and UCST⁴ have been used. In the opinion of the evaluators, the mutual solubilities calculated by this equation may be treated as tentative. The results of calculations for the selected temperatures are presented in the following table. This relationship, together with experimental points,^1,4 are also presented in Fig. 14.

Experimental Data:   (Notes on the Nomenclature)

Calculated mutual solubility of acetonitrile (1) and 1-dodecanol (2)

T/K	102 * Mass Fraction w1	Mole Fraction x1	Comment(s)
293.2	9.6	0.325	Alcohol-rich phase
298.2	13.7	0.418	Alcohol-rich phase
303.2	19.8	0.528	Alcohol-rich phase
304.2	21.5	0.554	Alcohol-rich phase
305.2	23.5	0.582	Alcohol-rich phase
306.2	25.9	0.614	Alcohol-rich phase
307.2	29.4	0.654	Alcohol-rich phase
307.7	31.8	0.679	Alcohol-rich phase
308.2	35.8	0.717	Alcohol-rich phase
308.3	37.2	0.729	Alcohol-rich phase
293.2	82.4	0.955	Acetonitrile-rich phase
298.2	81.4	0.952	Acetonitrile-rich phase
303.2	76.0	0.935	Acetonitrile-rich phase
304.2	74.2	0.929	Acetonitrile-rich phase
305.2	72.0	0.921	Acetonitrile-rich phase
306.2	68.8	0.909	Acetonitrile-rich phase
307.2	64.3	0.891	Acetonitrile-rich phase
307.7	61.1	0.877	Acetonitrile-rich phase
308.2	55.9	0.852	Acetonitrile-rich phase
308.3	54.0	0.842	Acetonitrile-rich phase

View Figure 14 for this Evaluation

References: (Click a link to see its experimental data associated with the reference)

   1  Hoerr, C.W.; Harwood, H.J.; Ralston, A.W., J. Org. Chem. 9, 267 (1944).
   2  Francis, A. W.; J. Phys. Chem. 60, 20 (1956).
   3  Schmid, H.H.O.; Mangold, H.K.; Lundberg, W.O., Microchem. J. 9, 134 (1965).
   4  Sazonov V.P.; Gudkina, L.V., Zh. Prikl. Khim. (Leningrad) 46, 1076 (1973).

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Last updated: February 18, 2015 (Created: August 17, 2007)