IUPAC-NIST Solubility Database
NIST Standard Reference Database 106

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 Solubility System: Acetonitrile with Cyclohexane

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Components:
   (1) Cyclohexane; C6H12; [110-82-7]  NIST Chemistry WebBook for detail
   (2) Acetonitrile; C2H3N; [75-05-8]  NIST Chemistry WebBook for detail

Original Measurements:
   Ott, J.B.; Purdy, J.E.; Neely, B.J.; Harris, R.A., J. Chem. Thermodyn. 20, 1079 (1988).

Variables:
   Temperature = 319 K to 348 K
   Pressure = 0.1 MPa to 15 Mpa

Prepared By:
   Valerii P. Sazonov

Experimental Data:   (Notes on the Nomenclature)
  

Table 1. Mutual solubility of acetonitrile (1) and cyclohexane (2) at ambient pressure

t/°C	T/K	102 * Mass Fraction w1 (compiler)	Mole Fraction x1	Comment(s)
45.53	318.68	-	-	Hydrocarbon-rich phase
47.81	320.96	5.71	0.1105	Hydrocarbon-rich phase
48.68	321.83	5.90	0.1139	Hydrocarbon-rich phase
55.48	328.63	7.79	0.1477	Hydrocarbon-rich phase
56.44	329.59	-	-	Hydrocarbon-rich phase
62.76	335.91	10.57	0.1951	Hydrocarbon-rich phase
63.47	336.62	10.84	0.1996	Hydrocarbon-rich phase
64.44	337.59	-	-	Hydrocarbon-rich phase
69.39	342.54	15.23	0.2692	Hydrocarbon-rich phase
70.46	343.61	-	-	Hydrocarbon-rich phase
72.79	345.94	19.90	0.3375	Hydrocarbon-rich phase
73.24	346.39	-	-	Hydrocarbon-rich phase
73.31	346.46	21.77	0.3633	Hydrocarbon-rich phase
74.15	347.30	25.14	0.4077	Hydrocarbon-rich phase
74.46	347.61	-	-	Hydrocarbon-rich phase
74.62	347.77	29.63	0.4633	Hydrocarbon-rich phase
74.68	347.83	32.59	0.4978	Hydrocarbon-rich phase
74.69	347.84	-	-	Hydrocarbon-rich phase
45.53	318.68	77.91	0.8785	Acetonitrile-rich phase
47.81	320.96	-	-	Acetonitrile-rich phase
48.68	321.83	-	-	Acetonitrile-rich phase
55.48	328.63	-	-	Acetonitrile-rich phase
56.44	329.59	71.72	0.8387	Acetonitrile-rich phase
62.76	335.91	-	-	Acetonitrile-rich phase
63.47	336.62	-	-	Acetonitrile-rich phase
64.44	337.59	65.14	0.7930	Acetonitrile-rich phase
69.39	342.54	-	-	Acetonitrile-rich phase
70.46	343.61	57.20	0.7326	Acetonitrile-rich phase
72.79	345.94	-	-	Acetonitrile-rich phase
73.24	346.39	50.34	0.6751	Acetonitrile-rich phase
73.31	346.46	-	-	Acetonitrile-rich phase
74.15	347.30	-	-	Acetonitrile-rich phase
74.46	347.61	43.57	0.6128	Acetonitrile-rich phase
74.62	347.77	-	-	Acetonitrile-rich phase
74.68	347.83	-	-	Acetonitrile-rich phase
74.69	347.84	38.56	0.5627	Acetonitrile-rich phase

Table 2. Mutual solubility of acetonitrile (1) and cyclohexane (2) at high pressure

t/°C	T/K	Pressure	102 * Mass Fraction w1 (compiler)	Mole Fraction x1	Comment(s)
50.00	323.15	0.4	6.23	0.1198	Hydrocarbon-rich phase
50.00	323.15	15.0	7.10	0.1355	Hydrocarbon-rich phase
75.00	348.15	15.0	17.58	0.3042	Hydrocarbon-rich phase
50.00	323.15	0.4	77.86	0.8649	Acetonitrile-rich phase
50.00	323.15	15.0	75.74	0.8782	Acetonitrile-rich phase
75.00	348.15	15.0	54.15	0.7077	Acetonitrile-rich phase

Method/Apparatus/Procedure:
   The synthetic method was used. The liquids to be mixed were injected into the sample vessel through the capillary tube. This tube was then sealed so that a sample was completely enclosed in an all-glass container except for a Teflon-coated magnetic stirring-rod placed in the vessel during construction. The volume of the sample vessel was approximately 25 mL and the total sample size was approximately 15 mL. The sample vessel was placed inside a temperature-control jacket, which in turn was surrounded by a vacuum jacket. A Rosemouth platinum thermometer passed down the tube at the top of the apparatus and into the thermometer well of the sample vessel. To measure the temperature, fluid was pumped through the circulating jacket and through a temperature controller programmed to heat or cool at a slow rate. The sample was stirred rapidly with a magnetic stirrer using the Teflon-coated stirring bar in the sample vessel. A glass spiral was fused to the thermometer well inside the mixing vessel to break up the swirling action of the stirrer and give better mixing. The equilibrium temperature was obtained visually as the value where the mixture became clear upon heating or cloudy upon cooling. Care was taken not to confuse critical opalescence with phase separation.

Source and Purity of Materials:
   (1) B and J Chrompure; purity of 99.9 mass %; used without further purification; dried over Davison 3 A molecular sieve.
   (2) MCB Spectro-grade; purity of 99.9 mass %; used without further purification; dried over sodium ribbon.

Estimated Errors:

   Temperature: ± 0.02 K.

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Last updated: February 18, 2015 (Created: August 17, 2007)